1.
Rev. bras. anestesiol
;
45(2): 131-40, mar.-abr. 1995. ilus, tab
Article
in Portuguese
| LILACS
| ID: lil-166850
2.
Indian J Physiol Pharmacol
;
1975 Apr-Jun; 19(2): 76-80
Article
in English
| IMSEAR
| ID: sea-106844
ABSTRACT
Six new substituted acylamides, chemically related to lignocaine were studied for local anaesthetic activity and toxicity in mice, frogs and guinea pigs. Only one of these compounds, w-pyrrolidino 2, 3, 5, 6 tetramethyl acetanilide was found to possess potency comparable to lignocaine with a slightly higher therapeutic index. Study of the S.A.R. of this group indicated that by removal of two methyl groups at position 3 and 5 in the above compound, a local anaesthetic with greater potency than lignocaine may be obtained. Further exploration of the potentialities of a compound having pyrrolidine group as a part of basic side chain is indicated.
Subject(s)
Acetanilides/analogs & derivatives , Anesthesia, Conduction , Anesthesia, Local , Animals , Anura , Cornea , Diethylamines/toxicity , Dimethylamines/toxicity , Guinea Pigs , Lethal Dose 50 , Lidocaine/analogs & derivatives , Mice , Morpholines/toxicity , Piperidines/toxicity , Propylamines/toxicity , Pyrrolidines/toxicity , Structure-Activity Relationship , Tail
3.
Indian J Exp Biol
;
1974 May; 12(3): 252-6
Article
in English
| IMSEAR
| ID: sea-62861